ABSTRACT
The coronavirus disease (COVID-19) pandemic has had a global impact on lives, livelihoods, and economies. This study investigates whether a contagious infectious disease can affect the prices of the Chinese and Korean stock markets. Specifically, we aim to discover discrepancies in the impact of COVID-19 on the stock prices of China and South Korea through panel data. To test these discrepancies, we first regressed the stock indices on confirmed cases and deaths. We then validated the stability of coefficients over the past days. The empirical results show that (1) responses of stock indices are stable and impulsive and (2) response patterns toward COVID-19 events considerably vary across nations, especially in the counties such as China and South Korea.
ABSTRACT
In order to treat Coronavirus Disease 2019 (COVID-19), we predicted and implemented a drug delivery system (DDS) that can provide stable drug delivery through a computational approach including a clustering algorithm and the Schrödinger software. Six carrier candidates were derived by the proposed method that could find molecules meeting the predefined conditions using the molecular structure and its functional group positional information. Then, just one compound named glycyrrhizin was selected as a candidate for drug delivery through the Schrödinger software. Using glycyrrhizin, nafamostat mesilate (NM), which is known for its efficacy, was converted into micelle nanoparticles (NPs) to improve drug stability and to effectively treat COVID-19. The spherical particle morphology was confirmed by transmission electron microscopy (TEM), and the particle size and stability of 300-400 nm were evaluated by measuring DLSand the zeta potential. The loading of NM was confirmed to be more than 90% efficient using the UV spectrum.